Synthesis of the Apratoxin 2,4-Disubstituted Thiazoline via an Intramolecular Aza-Wittig Reaction
- 28 March 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (8) , 1281-1283
- https://doi.org/10.1021/ol0342148
Abstract
[reaction: see text] In developing a synthetic entry to the thiazoline-containing domain of the apratoxin natural products, we converted vicinal azido-thiolesters into 2,4-disubstituted thiazolines via sequential one-pot Staudinger reduction/aza-Wittig reaction. This method of de novo thiazoline formation provides a mild and versatile process that is particularly well suited to acid-sensitive substrates.Keywords
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