Thiazide-Induced Hypercalcemia

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Abstract
IT is now frequently recognized that thiazide diuretics can appreciably influence calcium metabolism. A decrease in urinary calcium has been related to the oral administration of chlorothiazide and hydrochlorothiazide to normal subjects, and to patients with congestive heart failure.1 Other studies have indicated that healthy subjects2 3 4 and patients with metabolic bone disease2 , 5 6 7 and with idiopathic hypercalciuria2 , 5 6 7 8 9 also respond to thiazide administration with a reduction in urinary calcium.Hypercalcemia related to thiazide administration is relatively uncommon and has usually been associated with other pathologic conditions.2 , 7 , 10 , 11 The patient described below experienced hypercalcemia on several occasions when challenged by the administration of hydrochlorothiazide. . . .