PROGRESS REPORT ON CHLORAMBUCIL THERAPY IN POSTSPLENECTOMY PATIENTS WITH PROGRESSIVE HAIRY-CELL LEUKEMIA

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (3) , 464-467
Abstract
Of 8 patients with progressive hairy cell leukemia who were treated with daily doses of an alkylating agent (chlorambucil, 4 mg) for at least 6 mo. 7 have had an objective response, as measured by improved blood counts. Two patients were pancytopenic and had almost total bone marrow replacement with hairy cells at the initiation of chemotherapy; .apprx. 6 mo. later, their blood counts and bone marrow had improved dramatically. The 5 other patients had the leukemic form of the disease; all responded to therapy. It is important to identify postsplenectomy patients with progressive disease to initiate low-dose single-agent chemotherapy.