Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids
- 2 November 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (11) , 1264-1267
- https://doi.org/10.1021/jm00185a027
Abstract
A series of xanthone-2-carboxylic acids substituted in the 7 position with sulfamoyl and other groups was synthesized and assayed in vitro for inhibition of aldose reductase reductase isolated from rabbit lenses. At a concentration of 10-6 M, the N-methyl-N-(2-hydroxyethyl)sulfamoyl derivative produced an 83% inhibition of aldose reductase. The structural requirements for this type of activity are discussed. The compounds were studied for their possible use to prevent cataract formation.This publication has 6 references indexed in Scilit:
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