Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines
- 1 October 1990
- journal article
- conference paper
- Published by Springer Nature in Urological Research
- Vol. 18 (5) , 309-312
- https://doi.org/10.1007/bf00300777
Abstract
The natural resistance to doxorubicin of 15 human renal carcinoma cell lines was analyzed and compared to proliferative activity and expression of P-glycoprotein. We found a significant negative correlation between proliferative activity and natural resistance to doxorubicin, as well as between proliferative activity and the expression of P-glycoprotein. A positive correlation between resistance and expression of P-glycoprotein was found.Keywords
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