Influence of AGTH and Cortisone upon Alteration in Capillary Permeability Induced by Hyaluronidase in Rats.

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Abstract
Intraven. admn. of 2000 U. of partially purified testicular hyaluronidase in rats induced an increased rate of disappearance of Evans blue, a decreased concn. of serum protein, and an increased hematocrit. These manifestations of an increased capillary permeability due to the action of the enzyme prepn. were largely inhibited by 5 days pretreat-ment with subcut. admn. (5 mg./day) of either ACTH or cortisone acetate. A minimum of 24-48 hrs. of pretreatment with cortisone acetate was required for a discernible inhibition of the hyaluronidase effect. The evidence suggests an intermediate step between cortisone acetate and its action on connective tissue.

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