MOBILIZATION OF THE ANTIDIURETIC HORMONE AND THE SECRETION OF ACTH FOLLOWING COLD STRESS1

Abstract
The effect of hydration and dehydration on the pituitary-adrenal response to cold stress had been investigated. A normal stress response occurred in hydrated and dehydrated guinea pigs as determined by increases in urinary corticoid excretion. The antidiuretic activity in the hypothalamus and posterior pituitary was markedly diminished following dehydration. Apparently, conditions which induce alterations in mobilization of the antidiuretic hormone do not necessarily induce parallel alterations in the secretion of ACTH in response to stress.