Hormonal Control and Putative Cell Cycle Dependency of AFP Production: Further Observations in vivo and in vitro
- 1 October 1978
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 8 (s8) , 239-246
- https://doi.org/10.1111/j.1365-3083.1978.tb03928.x
Abstract
We describe the effect of hormones on AFP production in neonatal rats, in primary fetal rat hepatocyte cultures, in adult animals with liver injuries, and in tumor cell lines established in vitro. Preliminary data of studies on the putative cell cycle dependency of AFP production are also presented. Suppression of AFP by glucocorticoid hormones emerges as a most powerful system to study liver cell differentiation through AFP regulation.Keywords
This publication has 16 references indexed in Scilit:
- S‐adenosylmethionine Metabolism and AFP Expression: Is There a Direct Link?Scandinavian Journal of Immunology, 1978
- Detection of α-foetoprotein in mouse liver differentiated hepatocytes before their progression through S phaseNature, 1976
- α‐FETOPROTEIN AND ALBUMIN SYNTHESIS DURING THE CELL CYCLEAnnals of the New York Academy of Sciences, 1975
- α‐FETOPROTEIN SYNTHESIS IN CULTURED CELLS: STUDIES ON YOSHIDA SARCOMA AND ASCITES HEPATOMA IN VITROAnnals of the New York Academy of Sciences, 1975
- SYNTHESIS OF ?-FETOPROTEIN BY RAT ASCITES HEPATOMA CELLSAnnals of the New York Academy of Sciences, 1975
- DNA Replication and the Stability of Cell DifferentiationPublished by Elsevier ,1974
- A ROLE OF THE CELL CYCLE IN HORMONE-DEPENDENT DIFFERENTIATIONThe Journal of cell biology, 1974
- ALPHA1-FETOPROTEIN BIOSYNTHESIS DURING THE GROWTH CYCLE OF DIFFERENTIATED FETAL RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTUREThe Journal of cell biology, 1974
- Plasma adrenocorticosteroid changes during thyroxine-induced accelerated maturation of the neonatal rat intestineCellular and Molecular Life Sciences, 1974
- THE CONTROL OF EPIDERMAL THICKNESS*British Journal of Dermatology, 1972