Bayesian community-wide culture-independent microbial source tracking
Top Cited Papers
- 17 July 2011
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 8 (9) , 761-763
- https://doi.org/10.1038/nmeth.1650
Abstract
SourceTracker finds the proportion and origin of contaminants in a given sample. Its database will prove useful in screening of metagenomic datasets for contaminants. Contamination is a critical issue in high-throughput metagenomic studies, yet progress toward a comprehensive solution has been limited. We present SourceTracker, a Bayesian approach to estimate the proportion of contaminants in a given community that come from possible source environments. We applied SourceTracker to microbial surveys from neonatal intensive care units (NICUs), offices and molecular biology laboratories, and provide a database of known contaminants for future testing.Keywords
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