Activin A‐induced apoptosis is suppressed by BCL‐2
- 4 December 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 376 (3) , 247-250
- https://doi.org/10.1016/0014-5793(95)01290-7
Abstract
Activin A, a member of TGFβ superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL-2 and BAX, and the effect of BCL-2 overexpression on activin A-induced apoptosis in B cell hybridoma cell lines. The activin A-sensitive cell lines expressed BAX but not BCL-2 and that activin A did not increase BAX levels. Overexpression of human BCL-2 suppressed activin A-induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL-2-inhibitable mechanism without activating BAX.Keywords
This publication has 22 references indexed in Scilit:
- Induction of Apoptosis in B Lineage Cells by Activin A Derived from MacrophagesJournal of Interferon & Cytokine Research, 1995
- Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell deathCell, 1995
- Activin A Induces Apoptotic Cell DeathBiochemical and Biophysical Research Communications, 1993
- Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell deathCell, 1993
- bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell deathCell, 1993
- Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structuresCell, 1990
- Activin is a nerve cell survival moleculeNature, 1990
- Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsNature, 1988
- Purification and characterization of Erythroid Differentiation Factor(EDF) isolated from human leukemia cell line THP-1Biochemical and Biophysical Research Communications, 1987
- Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluidNature, 1986