Interstitial hyperthermia of experimental brain tumor using implant heating system

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Abstract
New experimental system of induction hyperthermia for brain tumor using ferromagnetic implant with low Curie point has been developed. The metal implant is cylindrical needle and made of Fe-Pt alloy with low Curie point suitable for hyperthermia (50–60°C). Induction coil and generator which produce maximum power of 200 W and variable frequency of 100–500 kHz, yielding magnetic power of 16.7 Oe, have been developed. Interstitial hyperthermia was made on rat brain tumor model (T9 gliosarcoma) by this system. Significant effects of single hyperthermia (45°C for 30 minutes) were observed by the extension of life span and morphological changes of the tumor.