H-2-ANTAGONISTIC ACTIVITY OF IMPROMIDINE ANALOGOUS CYANOGUANIDINES .37. H-2-ANTIHISTAMINICS
- 1 January 1988
- journal article
- research article
- Vol. 38-1 (1) , 7-10
Abstract
In studies on structure-activity relationships among impromidine-like histamine H2-receptor agonists, the synthesis of impromidine analogous guanidines led to the corresponding intermediate cyanoguanidines. The latter are structurally related to cimetidine. For that reason they were tested for H2-antagonistic activity on the isolated guinea-pig atrium. Compound 5h proved to be significantly more potent than cimetidine. Derivatives with branched thioether moiety were devoid of affinity. The results are consistent with existing structure-activity relationships.This publication has 7 references indexed in Scilit:
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