Endogenous inhibitor of prostaglandin synthetase
Open Access
- 1 November 1977
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 270 (5632) , 32-36
- https://doi.org/10.1038/270032a0
Abstract
Mammalian serum and plasma contain an endogenous inhibitor of prostaglandin synthetase (EIPS). Human plasma fractions rich in EIPS show anti-inflammatory activity in vivo. In rats, glucocorticoids raise EIPS activity of plasma and serum. These findings suggest the existence of a natural mechanism of controlling prostaglandin synthesis, possibly related to corticosteroid action.This publication has 19 references indexed in Scilit:
- Suppression of the release of prostaglandin-like substances by hydrocortisone in vivoProstaglandins, 1977
- THE LOCAL ANTINOCICEPTIVE AND TOPICAL ANTI‐INFLAMMATORY EFFECTS OF PROPYL GALLATE IN RODENTSBritish Journal of Pharmacology, 1976
- STIMULATION OF PROSTAGLANDIN BIOSYNTHESIS BY DRUGS: EFFECTS in vitro OF SOME DRUGS AFFECTING GUT FUNCTIONBritish Journal of Pharmacology, 1976
- Corticosteroids inhibit prostaglandin production by rheumatoid synoviaNature, 1975
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pigProstaglandins, 1975
- Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroidsNature, 1975
- Prostaglandins and the anti-inflammatory activity of a human plasma fraction in carrageenan-induced paw oedema in the ratJournal of Pharmacy and Pharmacology, 1974
- The use of the hamster stomach in vitro as an assay preparation for prostaglandinsBritish Journal of Pharmacology, 1973
- Prostaglandin biosynthesis by human skin and its inhibition by corticosteroidsBritish Journal of Pharmacology, 1972