THE LOCAL ANTINOCICEPTIVE AND TOPICAL ANTI‐INFLAMMATORY EFFECTS OF PROPYL GALLATE IN RODENTS

Open Access
Publisher Website
Google Scholar
Abstract
In common with several anti‐inflammatory, analgesic, local anaesthetic and antioxidant drugs, propyl gallate in vitro inhibited the biosynthesis of prostaglandin E2 and F2α from arachidonic acid by a prostaglandin synthetase from bull seminal vesicles. In common with analgesic drugs, propyl gallate reduced the ability of arachidonic acid, acetylcholine or acetic acid to cause abdominal constrictions in mice. Using a new method of evaluating anti‐inflammatory activity, we demonstrated the effectiveness of aspirin or indomethacin given subcutaneously before u.v. irradiation of guinea‐pig ears, the prophylactic action of topically applied sunscreen agents and the therapeutic value of bufexamac and propyl gallate applied after irradiation.

This publication has 22 references indexed in Scilit: