The Impact of Abnormalities in IGF and Inflammatory Systems on the Metabolic Syndrome
Open Access
- 1 November 2004
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 27 (11) , 2682-2688
- https://doi.org/10.2337/diacare.27.11.2682
Abstract
OBJECTIVE—Low plasma levels of IGF-I, particularly when coupled with low levels of the potentially inhibitory IGF binding protein (IGFBP)-1 and higher levels of C-reactive protein (CRP), have been implicated in the pathogenesis of metabolic syndrome X and cardiovascular disease. We report the relative contributions of IGFBP-1 and CRP to the occurrence of the metabolic syndrome in a healthy population cohort to establish the extent to which these factors may contribute to subsequent risk of cardiovascular disease.Keywords
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