Identification of Rickettsial Agents Isolated in Guinea Pigs by Means of Specific Complement Fixation

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Abstract
The difficulties in the identification of strains of epidemic and murine typhus or Rocky Mt. spotted fever based on animal reactions alone presents certain difficulties. This was illustrated when guinea pigs were inoculated at the same time with the same amt. of a pool of infectious material of these agents. Irrespective as to whether the guinea pig develops evidence of disease, as expressed by a febrile reaction or scrotal swelling, or an inapparent disease without these reactions, specific complement-fixing antibodies can be demonstrated in early convalescence. For this reason the specific complement-fixation test is recommended as a routine test to differentiate infections in guinea pigs caused by rickettsiae of murine and epidemic typhus, and Rocky Mt. spotted fever.

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