EFFECTS OF CIMETIDINE ON THYROID HORMONES

Publisher Website
Google Scholar
Abstract
Short-term administration of the H2-antagonist cimetidine (400 mg, 3 times/day for 5 days) was performed in 8 healthy male volunteers, and its effects on thyroid hormone levels and on hypophyseal hormone release induced by acute hypoglycemia and TRH were tested. Absolute values of basal and post-TRH serum T3 [triiodothyronine] were decreased by treatment, while basal and stimulated serum r[reverse]T3 and T4 [thyroxine] levels were not altered significantly. Cimetidine administration did not change the hormone release induced by acute hypoglycemia but significantly enhanced the prolactin and TSH responses to TRH. Evidently, cimetidine administration can modify the peripheral metabolism rather than the secretion of thyroid hormones.