Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion

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Abstract
Intraventricular infusion of the stable substance P analogue, DiMethyl-C7, was found to produce aversion in a place conditioning paradigm. This effect was independent of state dependent learning since the place aversion was also seen when the subjects were tested under the influence of the drug. A role for substance P in aversion is discussed.