The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin -N6- YL) Alkanes1
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (2) , 297-303
- https://doi.org/10.1080/07328318908054174
Abstract
Members of a series of α,ω-di(adenosin- N 6-yl)alkanes, comprising two adenosine residues linked with alkyl bridges from 1 to 14 methylene units in length, were found to be inhibitors of rat liver and BHK cell adenosine kinase. The inhibition was competitive with respect to adenosine and non-competitive with respect to ATP. The corresponding α,ω-di(cytidin-N 4-yl) alkanes were not inhibitors and N 6-alkyladenosines inhibited only weakly.This publication has 17 references indexed in Scilit:
- Biochemistry of terminal deoxynucleotidyltransferase (TdT): characterization and mechanism of inhibition of TdT by P1,P5-bis(5'-adenosyl) pentaphosphateBiochemistry, 1987
- Adenosine kinase from human erythrocytes: kinetic studies and characterization of adenosine binding sitesBiochemistry, 1987
- Inhibition of terminal deoxynucleotidyl transferase by adenine dinucleotidesFEBS Letters, 1987
- Synthesis of dicytidylyl-(3'-5')-1,2-di(adenosin-N6-yl)ethane and dicytidylyl-(3'-5')-1,4-di(adenosin-N6-yl)butane: covalently joined terminals of two transfer ribonucleic acids and their behavior toward snake venom phosphodiesteraseBiochemistry, 1980
- DIADENOSINE TETRAPHOSPHATE (AP4A) — A LIGAND OF DNA POLYMERASE α AND TRIGGER OF REPLICATIONPublished by Elsevier ,1979
- Simple models of nucleic acid interactions. 1. Base-base interactions in 1,2-di(adenosin-N6-yl)ethane and 1,4-di(adenosin-N6-yl)butaneThe Journal of Organic Chemistry, 1977
- Synthetic Inhibitors of Adenylate Kinases in the Assays for ATPases and PhosphokinasesEuropean Journal of Biochemistry, 1975
- Inhibition of rabbit skeletal muscle adenylate kinase by the transition state analogue, P1,P4-di(adenosine-5′)tetraphosphateBiochimica et Biophysica Acta (BBA) - Enzymology, 1972
- Studies of Phosphorylation. III. Selective Phosphorylation of Unprotected NucleosidesBulletin of the Chemical Society of Japan, 1969