The Vbeta8 Gene Family is Preferentially Used by'Naturally'Activated T Cells
- 1 July 1988
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 28 (1) , 69-74
- https://doi.org/10.1111/j.1365-3083.1988.tb02416.x
Abstract
Receptors encoded by the V.beta.8 gene family detected by the monoclonal antibody F23.1 are expressed among ''naturally'' activated T cells in normal spleen at frequencies significantly higher than in the total CD4+ and CD8+ cell populations. The positive selection of these clones into ''natural'' T-cell activity could be the reason for the high frequencies of cells expressing V.beta.8 genes. This phenotype is strain-dependent.Keywords
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