Characteristics of haloethylene-induced acetonemia in rats
- 1 July 1980
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 45 (2) , 109-116
- https://doi.org/10.1007/bf01270908
Abstract
A series of halogenated ethylenes (vinyl chloride, vinylidene fluoride,cis- andtrans-1,2-dichloroethylene, perchloroethylene) induces increased acetone exhalation in rats. Exposures of differently pre-treated rats to vinylidene fluoride suggest that a metabolite of the haloethylene must be envolved in eliciting this formation of acetone. This conclusion is based on (a) dependence of acetone exhalation on the concentration of vinylidene fluoride, (b) effect of inducing agents, (c) effect of pyrazol, a metabolic inhibitor, (d) effect of cysteine, (e) effect of hypoxia and (f) the time course of acetone exhalation.Keywords
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