Role of Noradrenergic Signaling by the Nucleus Tractus Solitarius in Mediating Opiate Reward
- 17 February 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 311 (5763) , 1017-1020
- https://doi.org/10.1126/science.1119311
Abstract
Norepinephrine (NE) is widely implicated in opiate withdrawal, but much less is known about its role in opiate-induced locomotion and reward. In mice lacking dopamine β-hydroxylase (DBH), an enzyme critical for NE synthesis, we found that NE was necessary for morphine-induced conditioned place preference (CPP; a measure of reward) and locomotion. These deficits were rescued by systemic NE restoration. Viral restoration of DBH expression in the nucleus tractus solitarius, but not in the locus coeruleus, restored CPP for morphine. Morphine-induced locomotion was partially restored by DBH expression in either brain region. These data suggest that NE signaling by the nucleus tractus solitarius is necessary for morphine reward.Keywords
This publication has 27 references indexed in Scilit:
- Dopamine β-Hydroxylase Knockout Mice have Alterations in Dopamine Signaling and are Hypersensitive to CocaineNeuropsychopharmacology, 2005
- Morphine reward in dopamine-deficient miceNature, 2005
- Prefrontal Cortical Norepinephrine Release Is Critical for Morphine-induced Reward, Reinstatement and Dopamine Release in the Nucleus AccumbensCerebral Cortex, 2005
- 5‐HT2A and α1b‐adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulantsEuropean Journal of Neuroscience, 2004
- Effects of morphine and morphine withdrawal on brainstem neurons innervating hypothalamic nuclei that control thepituitary‐adrenocortical axis in ratsBritish Journal of Pharmacology, 2002
- Cortical α1-adrenergic regulation of acute and sensitized morphine locomotor effectsNeuroReport, 2001
- Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the α1b-adrenoceptorEuropean Neuropsychopharmacology, 2000
- Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the ratJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1993
- Brain-stimulation reward: A review.Canadian Journal of Psychology / Revue canadienne de psychologie, 1991
- Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine SystemsAnnual Review of Neuroscience, 1979