Cortical α1-adrenergic regulation of acute and sensitized morphine locomotor effects
- 1 November 2001
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 12 (16) , 3483-3486
- https://doi.org/10.1097/00001756-200111160-00022
Abstract
The role of alpha1-adrenergic transmission was tested on locomotor effects of acute or repeated morphine (5 mg/kg, i.p.) administration. Prazosin, an alpha1-adrenergic antagonist, administered 30 min before morphine, either systemically (0.5 mg/kg, i.p.) or locally and bilaterally into the prefrontal cortex (200 pmol/side) reduced the stimulatory influence of morphine on locomotion. The progressive increase of the locomotor response induced by repeated morphine injections was blocked by a prazosin pretreatment but not the behavioral sensitization on the test day. These data suggest that blockade of cortical alpha1-adrenergic receptors reduces the expression of acute and sensitized locomotor responses to morphine, but does not prevent the induction of behavioral sensitization.Keywords
This publication has 24 references indexed in Scilit:
- Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTAPublished by Elsevier ,2002
- α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive functionBiological Psychiatry, 1999
- Dissociation of the α 2-adrenergic antinociception from sedation following microinjection of medetomidine into the locus coeruleus in ratsPain, 1994
- Blockade of Prefronto‐cortical α1‐Adrenergic Receptors Prevents Locomotor Hyperactivity Induced by Subcortical D‐Amphetamine InjectionEuropean Journal of Neuroscience, 1994
- External control of drug release and penetration: enhancement of the transdermal absorption of indomethacin by ultrasound irradiationJournal of Pharmacy and Pharmacology, 1991
- The effect of dopamine receptor blockade on the development of sensitization to the locomotor activating effects of amphetamine and morphineBrain Research, 1989
- Sensitization occurs to the locomotor effects of morphine and the specific μ opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbensBrain Research, 1987
- Morphine and Enkephalins Potently Inhibit [3H]Noradrenaline Release from Rat Brain Cortex Synaptosomes: Further Evidence for a Presynaptic Localization of μ‐Opioid ReceptorsJournal of Neurochemistry, 1987
- Long-term sensitization to the excitatory effects of morphineNeuropharmacology, 1983
- Neuroanatomical focus for morphine and enkaphalin-induced hypermotilityNature, 1977