Sexual differences in the storage and metabolism of iron

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Abstract
With the onset of sexual development, female rats have been found to accumulate Fe in their livers at a much greater rate than males. Removal of the gonads from male and female rats made the males store more and the females less iron in their livers, so that the concns. were equal for the 2 sexes. The admn. stilbestrol had no effect on the castrated males but it caused a slight increase in the Fe storage of the spayed females. The livers of sexually mature female rats, mice, hens and eels were shown to have a greater concn. of Fe in them than the livers of male animals at a corresponding stage of development. Guinea pigs, rabbits and perch were not found to exhibit these sex differences. Pregnancy rapidly reduced the Fe in the livers of female rats and the reaccumulation was comparatively slow.

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