Construction and Characterization of a Full-Length HIV-192UG001Subtype D Infectious Molecular Clone
- 1 January 2002
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 18 (1) , 85-88
- https://doi.org/10.1089/088922202753394754
Abstract
Here we report the construction, sequencing, and biological characterization of a molecular clone of HIV-192UG001, a virus representative of subtype D strains circulating in Uganda. The virus produced by the clone has an aggressive syncytium-inducing phenotype, which matches that of the parental virus. This phenotype may be related to duplication of a binding site for a transcription factor, T cell factor 1α (TCF-1α), in the long terminal repeat of the virus.Keywords
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