Effect of Anticoagulants on Local Shwartzman Reaction

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Abstract
Heparin and tromexan, when given in adequate dosage, inhibited the local Shwartzman reaction induced with a polysaccharide from S. marcescens. Two other anticoagulants, chlorazol fast pink and mepesulfate did not produce the requisite prolongation of clotting time, and failed to inhibit the Shwartzman reaction. These observations are consistent with the thesis that thrombosis may be one important factor in the development of the local Shwartzman reaction.

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