Hydroxyethyl starch induced acquired von Willebrand's disease
- 28 June 2008
- journal article
- case report
- Published by Wiley in Clinical and Laboratory Haematology
- Vol. 14 (3) , 209-211
- https://doi.org/10.1111/j.1365-2257.1992.tb00367.x
Abstract
Hydroxyethyl starch (HES) (Hespan, DuPont) is a widely used synthetic volume expander which in standard doses of up to 1.5l in 24 h has no significant effect on coagulation (Munsch et al. 1988). However, the data sheet states that in large volumes HES may alter the coagulation mechanism. We now report a case of HES induced acquired von Willebrand's disease (vWD) in which severe bleeding occurred.Keywords
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