Strong association of MuSK antibody–positive myasthenia gravis and HLA-DR14-DQ5
- 13 June 2006
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 66 (11) , 1772-1774
- https://doi.org/10.1212/01.wnl.0000218159.79769.5c
Abstract
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.Keywords
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