A Comparison of a Short Course of Single Daily Dosage Therapy of Tinidazole with Metronidazole in Intestinal Amoebiasis

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Abstract
Sixty patients with symptomatic intestinal amoebiasis were treated for 3 days with a single dose of 2 g of either tinidazole or metronidazole respectively by random order. Tinidazole cured 90% of patients (27/30) and metronidazole cured 53.3% of patients (16/30). The difference was significant (p < 0.01). Mild side-effects were reported by 26.7% of patients (8/30) in the tinidazole group as compared to mild to moderate side effects reported by 53.3% of patients (16/30) in the metronidazole group. The difference was statistically significant (p<0.05). As the average patient has only a limited understanding and toleration of extended treatment courses, the advantages of a short course employing a single daily dose are obvious. With such a regimen, tinidazole was found to be superior to metronidazole in intestinal amoebiasis.

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