NECESSITY OF BILE FOR AND LACK OF INHIBITORY EFFECT OF RETINOID ON DEVELOPMENT OF FORESTOMACH PAPILLOMAS IN NONTREATED MUTANT MICE OF THE W/WV GENOTYPE

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (9) , 3806-3809
Abstract
The pathogenesis of papillomas which developed spontaneously in the forestomach of WB .times. C57BL/6 F1-W/Wv mutant mice was investigated. The thickness of the forestomach epithelium was used as a quantitative index for development of papillomas. From the 15th day after birth, the forestomach epithelium of the W/Wv mice was significantly thicker than that of the congenic +/+ mice. Administration of aromatic retinoic acid analog (ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate) did not suppress development of papillomas. Since papillomas did not appear in the stomach which was removed from the W/Wv embryos and grafted to the s.c. space produced in the back of the adult mice and since a considerable amount of bile reflux preceded development of papillomas, bule reflux may be a cause of papillomas in W/Wv mice.