Memory T Lymphocytes Generated byMycobacterium bovisBCG Vaccination Reside within a CD4 CD44loCD62 LigandhiPopulation
Open Access
- 1 November 2005
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (11) , 7759-7764
- https://doi.org/10.1128/iai.73.11.7759-7764.2005
Abstract
In the lungs of mice vaccinated withMycobacterium bovisBCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44hiCD62 ligandlo(CD62Llo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44loCD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset.Keywords
This publication has 21 references indexed in Scilit:
- NIH pre-clinical screening program: overview and current statusTuberculosis, 2005
- Stable T-Cell Population Expressing an Effector Cell Surface Phenotype in the Lungs of Mice Chronically Infected with Mycobacterium tuberculosisInfection and Immunity, 2004
- Similarities and differences in CD4+ and CD8+ effector and memory T cell generationNature Immunology, 2003
- Remembrance of things pastNature, 2002
- Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivoNature Immunology, 2002
- Tuberculosis: Latency and ReactivationInfection and Immunity, 2001
- Immunology of TuberculosisAnnual Review of Immunology, 2001
- An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.The Journal of Experimental Medicine, 1993
- Disseminated tuberculosis in interferon gamma gene-disrupted mice.The Journal of Experimental Medicine, 1993
- T Cell Response to Mycobacterium tuberculosisThe Journal of Infectious Diseases, 1993