FACTORS AFFECTING THE MAINTENANCE OF COBALT POLYCYTHEMIA IN THE RAT

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Abstract
Whole liver powder, liver extract (Wilson''s) and a P.A. concentrate for oral use (Lilly) when added to a milk diet produced and maintained a higher level of cobalt polycythemia. Casein had a very slight supplementary effect whereas liver residue (Wilson''s) had none. When the Ca-P ratio of the milk was decreased to 0.6 by the addition of NaH2P04 the rate of development of polycythemia increased with a resulting toxicity and depression of growth. Fluctuations in the Hb levels of polycythemic rats are largely prevented by preventing unnecessary loss of blood. By the use of a sharp scalpel or razor blade the lateral vein of the tail is severed without cutting through the tail; the resulting cut bleeds freely and is readily sealed by pressure over the wound.

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