Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40.

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Abstract
The frequency of mutants among the descendents of intact parvovirus H-1 was increased when cells of human and rat origin were exposed to UV light prior to infection. An enhanced mutagenesis of intact H-1 could be induced to almost the same extent in unirradiated cells by preinfecting them with H-1 or SV40 that had been irradiated with UV light. The expression of an enhanced mutagenesis of unirradiated H-1 after cell treatment with UV light or UV-irradiated virus was delayed, transient and dose-dependent, and it was dependent on de novo protein synthesis.