INFLUENCE OF NON‐H‐2 GENES ON THE IN VIVO RESPONSE TO PENICILLIN‐TREATED AUTOLOGOUS PLATELETS

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Abstract
SUMMARY: Mice of different inbred strains were injected intravenously on day O and 6 with autologous platelets incubated in a penicillin solution. After the second injection mice of most strains died immediately with anaphylactic symptoms. Both passive transfer experiments and indirect immunofluorescence studies suggest that a serum factor (probably IgM) is involved in this phenomenon. Only mice with a C3H background were unable to respond to autologous penicillintreated platelets, although C3H platelets did induce a lethal response in B10.A mice. Experiments in which B10.A mice were primed with autologous penicillin‐treated platelets and rechallenged with allogeneic penicillin‐treated platelets, showed that the response is directed against a polymorphic non‐H‐2 antigen in combination with penicillin.