Group sequential designs using both type I and type II error probability spending functions
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Communications in Statistics - Theory and Methods
- Vol. 27 (6) , 1323-1339
- https://doi.org/10.1080/03610929808832161
Abstract
We propose flexible group sequential designs using type I and type II error probability spending functions. The proposed designs preserve the overall significance level and power and allow the repeated testing to be perloimed at a flexible schedule. Computational methods are described. An example on a mega clinical trial is provided.Keywords
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