Acute Renal Failure due to Radio-Contrast Agents

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Abstract
Over a 2-yr period, acute renal failure following radio-contrast studies was observed in 25 patients after i.v. urography in 13, angiography in 10, oral cholecystography in 1 and cholangiography in 1. Twenty had impaired renal function prior to the study. Renal failure, oliguric in 16 patients, occurred within 24 h. Serum creatinines reached levels of 5.3-13.3 mg% in 3-10 days. Recovery occurred in 20 patients within 5-37 days. Among the 5 patients in whom renal function was not restored, 1 died of progressive underlying renal disease and 4 of other causes while still in acute renal failure. These observations demonstrate the not infrequent occurrence of severe oliguric renal failure following radio-contrast study in patients with preexisting renal disease.