Effects of some chlorinated sugar derivatives on the hexose transport system of the blood/brain barrier
- 15 June 1979
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 180 (3) , 677-679
- https://doi.org/10.1042/bj1800677
Abstract
The inhibition of D-glucose transport into brain by several hexose analogues was investigated in adult anesthetized rats. D-Glucose was transported with apparent Vmax = 1.22 .mu.mol/g per min, Km = 11.12 mM and Kd = 0.008 ml/g per min. 6-Chloro-6-deoxyglucose was transported with corresponding values of Vmax = 1.33 .mu.mol/g per min, Km = 5.5 mM and Kd = 0.0155 ml/g per min and inhibited D-glucose transport with apparent Ki = 3.01 mM. 6-Chloro-6-deoxymannose, 6-chloro-6-deoxygalactose and 6-tosyl-6-deoxygalactose also inhibited D-glucose transport, but 6-chloro-6-deoxyfructose was without effect. The results were consistent with a model for glucose transport at the blood/brain interface that involves a hydrophobic site on the transport protein at or near the 6-position of bound glucose.This publication has 13 references indexed in Scilit:
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