INVIVO AND INVITRO EFFECT OF BACTERIAL-ENDOTOXIN ON ERYTHROID PRECURSORS (CFU-E AND ERC) IN BONE-MARROW OF MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 89  (2) , 278-284
Abstract
Erythropoietin injection raised within 24 h the number of CFU-E [erythroid colony forming units] in the femoral marrow of polycythemic mice by 837%. Endotoxin [from Salmonella typhosa] given at 0-24 h before erythropoietin nearly abolished this CFU-E increase. Endotoxin in the culture medium did not inhibit erythroid colony formation, but in vivo endotoxin suppressed erythropoietin-induced differentiation of proerythroblasts from their precursors. Endotoxin thus suppresses marrow erythropoiesis either by inhibiting transformation of erythroid precursors into CFU-E or by causing the disappearance, perhaps by emigration, of CFU-E from the marrow.