SURVIVAL AND RECOVERY OF HUMAN-PLATELETS STORED FOR 5 DAYS IN A NONPLASMA MEDIUM

  • 1 March 1986
    • journal article
    • research article
    • Vol. 67  (3) , 672-675
Abstract
Human blood platelets were stored for five days as concentrates in 60 mL of: (a) plasma; (b) non-plasma medium with anticoagulant; and (c) non-plasma medium without anticoagulant. All preparations were equally functional when tested for platelet aggregation and release reaction in response to single agonist or synergistic pairs of agonists in vitro. Platelets stored in non-plasma medium with anticoagulant had lower kallikrein, fibrino(gen)peptide A, lactate, and .beta.-thromboglobulin than did plasma controls after five days. In vivo recovery and survival of platelets stored in non-plasma medium with anticoagulant were 51.2% .+-. 4.3% and 8.7 .+-. 0.3 days, respectively, which were not statistically different from plasma controls of 39.2% .+-. 4.9% and 7.2 .+-. 0.8 days, respectively. It is concluded that platelets can be stored for five days in a non-plasma medium and still have good in vivo recoveries and survivals.