The Total Synthesis of Dehexyl-deisovaleryloxy-antimycin A1
- 1 March 1970
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 43 (3) , 897-901
- https://doi.org/10.1246/bcsj.43.897
Abstract
A biologically active prototype of antimycin A series has been synthesized. The dilactone moiety was synthesized from a masked l-threonine and γ-hydroxyvalerate and condensed with an O-masked derivative of 3-nitrosalicylic acid N-hydroxysuccinimide ester. Hydrogenation followed by formylation afforded the anti-fungal substance. This synthesis established a possible general synthetic pathway to the members of antimycin A.This publication has 7 references indexed in Scilit:
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