Rearrangements of immunoglobulin and TCR genes in lymphoid blast crisis of Ph + chronic myeloid leukaemia

Publisher Website
Google Scholar
Abstract
Summary: Clonal rearrangements of immunoglobulin heavy chain genes as well as both T cell receptor (TCR) δ and γ genes were found in four cases of blast crisis of Ph + chronic myeloid leukaemia with unequivocal B cell precursor (common) immunophenotype. In one case, the TCR β chain gene was also rearranged. Although the developmental sequence of TCR δ, γ and β rearrangements in T lymphocytes appeared to be respected, a full phenotypic effect, characteristic of T cell was not observed in these otherwise typical ‘common’ blast cells. Cytogenetic analysis ruled out the occurrence of TCR rearrangement due to structural chromosome changes. A high incidence of unexpected TCR gene rearrangements has been previously reported in the de novo‘common’ acute lymphoblastic leukaemias (ALL). Our cases of chronic myeloid leukaemia (CML) in lymphoid blast crisis show that genotypic similarities may exist between these two haematological entities.