Human T-Cell γ Chain Genes: Organization, Diversity, and Rearrangement
- 17 January 1986
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4735) , 252-255
- https://doi.org/10.1126/science.3079918
Abstract
The human T-cell gamma chain genes have been characterized in an attempt to better understand their role in immune response. These immunoglobulin-like genes are encoded in the genome in variable, joining, and constant segments. The human gamma genes include at least six variable region genes, two joining segments, and two constant-region genes in germline DNA. Variable and joining segments recombine during the development of T cells to form rearranged genes. The diversity of human gamma genes produced by this recombinational mechanism is greater than that produced by the murine genome but is more limited than that of other immunoglobulin-like genes.Keywords
This publication has 10 references indexed in Scilit:
- Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7Nature, 1985
- A one and a half receptor model for MHC-restricted antigen recognition by T lymphocytesCell, 1985
- Limited diversity of the rearranged T-cell γ geneNature, 1985
- Structure, organization, and somatic rearrangement of T cell gamma genesCell, 1985
- T cell antigen receptors and the immunoglobulin supergene familyCell, 1985
- A third type of murine T-cell receptor geneNature, 1984
- A third rearranged and expressed gene in a clone of cytotoxic T lymphocytesNature, 1984
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequencesNature, 1984
- Sequence relationships between putative T-cell receptor polypeptides and immunoglobulinsNature, 1984
- A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chainsNature, 1984