Riboflavin in Human Serum

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Abstract
The riboflavin content of normal human serum was investigated. In 141 normal well-nourished persons, free serum riboflavin and FAD were 0.84 and 2.32 μg %, with standard deviations of 0.71 and 0.42 μg %, respectively. There were no differences between sexes and age groups. The microfluorometric method employed in this investigation gave an error much less than the variations that might be expected in any individual, hence it is suggested that duplicate determinations may be omitted in field survey techniques. It was found that nitrogen balance and riboflavin intake had no appreciable influence on serum riboflavin levels, provided that bleeding were done several hours after riboflavin intake. Serum riboflavin values, especially FAD, should be of value in the diagnosis of human riboflavin deficiency.