THE SUSCEPTIBILITY OF BALB/C AND OTHER INBRED MOUSE STRAINS TO BRUGIA-PAHANGI

  • 1 January 1983
    • journal article
    • research article
    • Vol. 40  (4) , 341-350
Abstract
The suceptibility of several strains of inbred mice to infection with the filarial worm B. pahangi was examined. BALB/C, C57BL/10, C3H/He, 101, CBA/Ca mice, congenitally asplenic (DH/+) mice and their normal litter-mates (+/+) were each challenged by the i.p. inoculation of 50 infective larvae. During the first 4 wk of infection high (19-42%) larval recoveries were obtained from the CBA/Ca, BALB/C and Dh/+mice but fewer than 10% of inoculated larvae were recovered from C3H/He, 101; C57BL/10 and +/+ mice. Larval growth rates in all mice were similar. BALB/C and Dh/+ mice only were examined later than 4 wk after infection. The yield of adult worms from BALB/C was 7.5% at 16 wk and from Dh/+ 4.2% at 21 wk. Microfilariae were present in the peritoneal fluids but not the blood of some mice harboring both adult male and female worms.

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