Antinuclear factors in murine alloantisera

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Abstract
Anti-Thy 1.1 and certain H-2 alloantisera contain an antinuclear factor (ANF) detected by fluorescent anti-mouse IgG. The incidence of ANF positive antisera reported here may actually be an underestimate. ANF is present in sera from this laboratory and from other sources; thus, ANF is not an artifact of this laboratory. ANF is not identical to alloantibody and the ANF appears to be of an autoimmune nature. A variety of environmental and genetic factors may influence the appearance of ANF in anti-H-2 sera, but the consistent detection of ANF in sera directed against H-2.31,34 or against H-2,4 suggests that some specific aspect of immune stimulation by these H-2 antigens, and likely by other H-2 antigenic specifications, induces the appearance of ANF. Whether these K and D antigens or other determinants associated with the H-2 complex may actually provide the immune stimulation for ANF induction is not known nor is the particular mechanism that may be operating to induce ANF.