Severe reversible azotemia from captopril therapy. Report of three cases and review of the literature

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Abstract
Three cases of severe reversible azotemia secondary to captopril therapy in hypertension were observed. All patients had extensive peripheral vascular disease involving the renal arteries, and 2 patients (patients 2 and 3) had high levels of peripheral plasma renin activity. The azotemia occurred approximately 2 wk after exposure to captopril, and fever, a maculopapular pruritic cutaneous rash and eosinophilia developed in 2 patients (patients 2 and 3). The cause of the azotemia in our patients is not clearly known, since renal biopsies were not performed. The most likely cause for the azotemia was volume contraction with reduction in the glomerular filtration rate, although a direct insult to the kidney could not be excluded.