Application of carboxylic-phosphinic mixed anhydrides in the fragment peptide synthesis of protected analogues of substance P
- 12 January 2009
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 38 (4) , 308-313
- https://doi.org/10.1111/j.1399-3011.1991.tb01509.x
Abstract
Mixed carboxylic-phosphinic anhydrides derived from peptide acids and 1-oxo-1-chlorophospholane have been applied in the synthesis of the protected [Leu11]-SP by the fragment coupling strategy. The yields from fragment couplings were ca. 75%, the products were of high purity while the conditions of formation and coupling of the corresponding mixed phosphinic anhydrides, for optimum yields, have been evaluated.Keywords
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