Bile Acid Metabolism, Dietary Fats, and Plasma Cholesterol Levels.

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Abstract
Soy oil (I2 No. 121) or corn oil (I2 No. 120) increased the absorption of simultaneously fed cholesterol into the intestinal lymph of 10 rats to 23 mg/24 hours, as compared with similar groups fed lard (I2 No. 59) or coconut oil (I2 No. 6) which absorbed 14 and 9 mg/24 hours, respectively. In another experiment 6 rats fed walnut oil (I2 No. 132) for 7 days had a plasma cholesterol level of 43 mg/100 ml as compared with levels of 62 and 52 mg/100 ml for similar groups fed coconut oil or fat-and-sterol-free diet, respectively. At the end of the 7 days excretion of bile acids in fistula bile averaged 58 mg/24 hours in the walnut oil group against 43 and 25 mg/24 hours in the coconut oil and fat-free groups, respectively. The excretion of cholesterol in fistula bile was 2.1 mg/day in the walnut oil group and 1.6 and 1.2 mg in the other 2 groups, respectively. Unsaturated fat probably increases removal of bile acids from the body and this removal provokes increased cholesterol conversion to bile acid which results in reduction of plasma cholesterol.