Effects of Ticlopidine on Platelet Function and Blood Coagulation

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Abstract
A double blind study was performed on 20 atherosclerotic patients. A placebo was administered to one group of 10 patients (group A) and ticlopidine (500 mg/day) was administered to another group of 10 patients (group B) for one month. ADP and collagen-induced platelet aggregation (PA), platelet malondial-deyde (MDA) produced by thrombin stimulation and plasma beta-thromboglobulin (βTG) levels, prothrombin time, activated partial thromboplastin time (APTT) fibrinogen, antithrombin (AT) III, fibrin(ogen) degradation products, alpha2-antiplasmin and plasminogen were evaluated in both groups before and after treatment. No changes in PA, MDA and βTG were seen in group A. Group B showed a significant decrease of PA, βTG and a significant increase of MDA. No changes on blood coagulation data were seen in either group. This study suggests that ticlopidine is able to inhibit platelet function in vivo.