The Determination of Metribuzin and Its Metabolites by High Pressure Liquid Chromatography

Abstract
A method for the determination of metribuzin [a systemic herbicide] and its metabolites in plant tissues [Glycine max cv. Ransom] was developed using high pressure liquid chromatography (HPLC). The system used involves reversed-phase chromatography on a C-18 HPLC column and a 62:38 methanol/0.05 M acetic acid mobile phase. Under these conditions, metribuzin and the 3 known metabolites [deaminated metribuzin (DA), deaminated diketometribuzin (DADK) and diketometribuzin (DK)] are completely resolved from each other. Detection is by UV absorbance at 254 nm.